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KMID : 0604520130390030215
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Journal of the Society of Cosmetic Scientists of Korea
2013 Volume.39 No. 3 p.215 ~ p.224
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Use of Oil Red O Staining Method in Non-Comedogenic Test for Cosmetics
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Lee Sun-Hwa
Lee Jung-Im
Kim Yoo-Ri
Lee Bum-Chun
Kang Min-Ji
Choi Gwang-Seong
Moon Tae-Kee
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Abstract
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It has been reported that certain ingredients added to cosmetics clog the skin pores and this can cause outbreaksof comedones which are the primary sign of acne leading to inflammatory acne. This research aims to establishobjective evaluation criteria for non-comedogenic cosmetics suitable for acne prone skin. The research has been carriedout to examine non-comedogenic test performed in foreign clinical institutions and to establish the evaluation methodfor detecting comedones outbreaks through repetitive closed back-patch test, Also, usability evaluation on face skin isperformed additionally to the same subjects. The analysis of the comedones collected through repetitive closedback-patch test confirmed that the test products, moisturizer and sunscreen product, did not cause comedones. Theseresults had no correlation with the analysis result of the comedones collected from face skin or visual evaluation ofacne by Global Acne Grading System (GAGS) in face usability test. Additionally, Oil red O staining was performedon the collected comedones specimen for easy distinction of comedones from hair follicle in image analysis. The analysisresult of stained specimen showed higher precision than that of non-stained specimen. This study established a newversion of non-comedogenic test for cosmetics, whose objectivity and reliability were improved by inclusion of comedonesstaining step.
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KEYWORD
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acne, acne cosmetics, noncomedogenic, microcomedone, follicular biopsy
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